We're not getting any younger... yet.
Why do some of us age gracefully and others don’t? How do our bodies and minds experience aging at the cellular and molecular level? Why do we even age to begin with? And maybe most importantly, can we do anything about it? Join host Gordon Lithgow at the Buck Institute in California as he speaks with some of the brightest scientific stars on the planet to search for – and actually find answers to – these questions and many more.
Episodes
26 episodes
Nathan Price: Scientific Wellness and AI at the Forefront
What do we really want from our healthcare system, and how can AI help us get it sooner? In our final episode of season two, Gordon talks with visionary systems biology expert Nathan Price about the emergence of scientific wellness, what we can...
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32:30
Luigi Ferrucci: Resilience as Medicine
Few people have as much experience with patient care and long-term research as the celebrated geriatrician and epidemiologist Luigi Ferrucci. Listen in as he speaks with Gordon about his journey from acute care to population studies, the effect...
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Season 2
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Episode 7
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46:14
Andrea Maier: From Potential to Practice
The movement to integrate longevity treatments into clinical care is making strides. How can we ensure they are evidence-based, accessible, and personalized? World-renowned geroscientist Andrea Maier has been leading the way with innovative cli...
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Season 2
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Episode 6
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36:23
Daniel Belsky: Measuring the Pace of Aging
Our chronological age doesn’t tell us much about how well our bodies are aging, but scientists have developed many ways to measure changes at the cellular and molecular levels, including the rate of change, that can suggest ways to improve heal...
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Season 2
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Episode 5
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38:57
Kristen Fortney: Finding Targets for Aging Interventions
Of all the biochemical changes that occur with aging, what really matters? How can we use the incredible amount of health data available today to discover the best targets for interventions? In this episode, Kristen Fortney of BioAge talks with...
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Season 2
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Episode 4
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26:58
Valter Longo: Fasting for Health and Longevity
What is the relationship between diet, chronic disease, and aging? Can we delay or reverse the effects of aging at the cellular level by following a fasting-mimicking diet? Listen in as Gordon speaks with Valter Longo of the Longevity Institute...
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Season 2
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Episode 3
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29:10
Satchin Panda: The Age of Circadian Disruption
Our modern world is full of potential disruptions to sleep. But as we learn more about circadian rhythm, we find that it influences everything from metabolism to mental health in different ways as we age. In this episode, Satchin Panda of the S...
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31:03
Laura Carstensen: The Purpose and Promise of Longer Lives
What is the goal of living longer? It’s not simply to celebrate a number, but to do something meaningful with that time. Renowned Stanford psychologist Laura Carstensen speaks with Gordon about the experience of aging, in the past and in the fu...
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Season 2
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Episode 1
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37:58
Season Two Coming Soon!
We're back! In season one, we investigated the biology of aging in many different organisms to learn why and how we age. This season we'll take a close look at potential interventions that modify mechanisms of aging biology and may dramatically...
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Season 2
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1:13
Between the lines: Mobilizing the immune system
Gordon and Stella revisit key concepts from the conversation with Arne Akbar, such as using sestrins to modulate T-cells and telomeres. Looking back over the course of season one, Stella and Gordon discuss the need to think about aging as an or...
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Season 1
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12:47
Arne Akbar: Immunity and Beyond
What role does the immune system play in aging? How do senescent cells evade it and promote inflammation? And what does it reveal about developing effective interventions? Immunologist Arne Akbar joins Gordon to break down the array of actors a...
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Season 1
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Episode 8
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33:21
Between the lines: The many fates of cells
After the conversation with Monica Driscoll, Gordon and show editor Stella connect to discuss the link between cell death and aging, what we can learn from sending worms to space, and the need for personalized medicine in aging interventions. F...
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Season 1
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10:21
Monica Driscoll: Exploring the Wild World Within
How do different cells in our bodies age differently? What exactly happens when a neuron takes out its trash? In this episode, neuroscientist Monica Driscoll takes Gordon on a tour through her serendipitous career. Topics include sloppy develop...
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Season 1
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Episode 7
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38:58
Between the lines: Genetics and geroprotectors
After a wide-ranging conversation with Nir Barzilai, Gordon and show editor Stella discuss efforts to turn research on geroprotective mechanisms into effective interventions, and look forward to the next episode with neuroscientist Monica Drisc...
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Season 1
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4:25
Nir Barzilai: The Secrets of Centenarians
Is aging truly inevitable? Can we study the genetics of long-lived people to learn how to delay or reverse aging? In this episode, Gordon talks with Dr. Nir Barzilai about his research on centenarians, insulin signaling pathways, and moving agi...
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Season 1
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Episode 6
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45:44
Between the lines: Trade-offs and timing in aging interventions
Gordon and show editor Stella revisit key concepts from the conversation with Linda Partridge, such as what we can learn from evolutionary biology and how to harness biological processes like autophagy. Looking ahead, they anticipate discussing...
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Season 1
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6:20
Linda Partridge: The Nature of Aging
Aging appears to progress similarly across species, from worms and flies to mice and humans, and involves pathways related to early development. Guest Linda Partridge talks with Gordon while visiting the Buck Institute to discuss the evolutiona...
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Season 1
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Episode 5
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36:44
Between the lines: Stress and aging
Following the episode with Rhonda Patrick, Gordon and Stella discuss the complex relationship between stress and aging, and preview the next conversation with Linda Partridge.The show will return in January 2023. Happy Holidays!
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Season 1
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4:17
Rhonda Patrick: Training to Age Better
What is the relationship between stress, metabolism, and aging? How can we use “good” stress to enhance our ability to weather the challenges of getting older? Guest Rhonda Patrick has investigated the biology of aging and related lifestyle int...
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Season 1
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Episode 4
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50:34
Between the lines: Senescence and aging
Gordon and Stella revisit the discussion with Judy Campisi to understand the role senescence plays in aging, and look forward to the next conversation with longevity expert Rhonda Patrick.
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Season 1
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4:38
Judy Campisi: Understanding Senescence
Dr. Campisi has been at the forefront of studying cellular senescence for decades, revealing the mysteries of these not-exactly-dead cells and their role in many diseases of aging. In this episode, she joins her colleague Gordon to discuss the ...
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Season 1
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Episode 3
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45:45
Between the lines: Using information theory to reverse aging
Gordon and show editor Stella revisit highlights from the conversation with David Sinclair, and get ready for the next episode with Judy Campisi.
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Season 1
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3:50
David Sinclair: An Information Theory of Aging
Is life essentially an information process driven by biochemical interactions? If so, can we simply correct any errors in that process? In this episode, renowned researcher and author David Sinclair joins Gordon to dive into the startling insig...
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Season 1
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Episode 2
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48:26